General information about the entry
Entry name HS_TNF
Entry type standard
Promoter type single
Accession number EP11158
Description of the gene Tumor necrosis factor-alpha, TNF or TNFA gene.
Creation date ??-APR-1987 (Rel. 11)
Last annotation 22-MAR-2005 (Rel. 82)
Taxonomic division VRT
Organism Homo sapiens (human)
Keywords Cytokine, Cytotoxin, Transmembrane, Glycoprotein.
Similarities with other entries
Homology group Homology group 211; Mammalian tumor necrosis factor alpha
Alternative promoter none.
Neighbouring promoter(s) none.
Cross References
GENOME NT_007592.14 [-22401588, 26544302] ENSEMBL ContigView
UCSC Genome Browser
HapMap
CLEANEX HS_TNF
DNA References BA000025.2 [368465, -1861352] ENA GenBank DDBJ
Y14768.1 [44051, -37749] ENA GenBank DDBJ
Z15026.1 [5380, -10930] ENA GenBank DDBJ
AF129756.1 [174484, -10182] ENA GenBank DDBJ
M16441.1 [-4093, 3019] ENA GenBank DDBJ
L11698.1 [-1052, 126] ENA GenBank DDBJ
X02910.1 [-614, 3020] ENA GenBank DDBJ
U42625.1 [-395, 202] ENA GenBank DDBJ
M26331.1 [-388, 2715] ENA GenBank DDBJ
E01989.1 [-314, 181] ENA GenBank DDBJ
AB088112.1 [-4188, 2786] ENA GenBank DDBJ
AB103618.1 [-4188, 2786] ENA GenBank DDBJ
AB202113.1 [-4188, 2786] ENA GenBank DDBJ
AL662801.7 [-48231, 84099] ENA GenBank DDBJ
AL662847.6 [-61997, 73787] ENA GenBank DDBJ
AL929587.5 [-23391, 37967] ENA GenBank DDBJ
AY066019.1 [-588, 4242] ENA GenBank DDBJ
AY214167.1 [-1737, 5503] ENA GenBank DDBJ
BX248519.7 [-7954, 32206] ENA GenBank DDBJ
SWISSPROT P01375 TNFA_HUMAN
TRANSFAC R03186 HS$TNFA_01 [-125, -81]; by position
R08185 HS$TNFA_02 [-160, -142]; by position
R08186 HS$TNFA_03 [-121, -106]; by position
R08187 HS$TNFA_04 [-104, -86]; by position
R08188 HS$TNFA_05 [-84, -66]; by position
R14422 HS$TNFA_06 [-186, -173]; by position
R14423 HS$TNFA_08 [-174, -159]; by position
R14470 HS$TNFA_10 [-112, -91]; by position
R14565 HS$TNFA_11 [-103, -83]; by position
R14622 HS$TNFA_12 [-60, -25]; by position
R14623 HS$TNFA_13 [-78, -68]; by position
R14625 HS$TNFA_15 [-120, -107]; by position
R14632 HS$TNFA_16 [-172, -149]; by position
R14707 HS$TNFA_18 [-186, -173]; by position
R14708 HS$TNFA_17 [-60, -43]; by position
R21079 HS$TNFA_21 [-117, -81]; by position
R21082 HS$TNFA_22 [-117, -63]; by position
R24498 HS$TNFA_24 [-217, -199]; by position
R24499 HS$TNFA_25 [-112, -92]; by position
R24500 HS$TNFA_26 [-112, -92]; by position
REFSEQ NM_000594 [ DBTSS ]
MIM 191160
References
[1] MEDLINE=2995927
Nedwin G.E., Naylor S.L., Sakaguchi A.Y., Smith D., Jarrett-Nedwin J., Pennica D., Goeddel D.V., Gray P.W.
"Human lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization"
Nucleic Acids Res. 13:6361-6373(1985).
Promoter-specific information
Sequence cgccctcctctcgccccagggacatataaaggcagttgttggcacacccAGCCAGCAGAC
Method(s) Nuclease protection with homologous sequence ladder [1].
Taxonomy 6. Vertebrate promoters
6.1. Chromosomal genes
6.1.5. Hormones, growth factors, regulatory proteins
6.1.5.11. Tumor necrosis factors
Supplementary information Expression/Regulation: monocytes, macrophages;+LPS
5-prime end distribution
No 5' end distribution available


Last update 02 Mar. 2012