ID   HS_TNF     standard; single; VRT.
XX
AC   EP11158;
XX
DT   ??-APR-1987 (Rel. 11, created)
DT   22-MAR-2005 (Rel. 82, Last annotation update).
XX
DE   Tumor necrosis factor-alpha, TNF or TNFA gene.
OS   Homo sapiens (human).
XX
HG   Homology group 211; Mammalian tumor necrosis factor alpha
AP   none.
NP   none.
XX
DR   GENOME; NT_007592.14; NT_007592; [-22401588, 26544302].
DR   CLEANEX; HS_TNF.
DR   EMBL; BA000025.2; [368465, -1861352].
DR   EMBL; Y14768.1; [44051, -37749].
DR   EMBL; Z15026.1; [5380, -10930].
DR   EMBL; AF129756.1; [174484, -10182].
DR   EMBL; M16441.1; [-4093, 3019].
DR   EMBL; L11698.1; [-1052, 126].
DR   EMBL; X02910.1; [-614, 3020].
DR   EMBL; U42625.1; [-395, 202].
DR   EMBL; M26331.1; [-388, 2715].
DR   EMBL; E01989.1; [-314, 181].
DR   EMBL; AB088112.1; [-4188, 2786].
DR   EMBL; AB103618.1; [-4188, 2786].
DR   EMBL; AB202113.1; [-4188, 2786].
DR   EMBL; AL662801.7; [-48231, 84099].
DR   EMBL; AL662847.6; [-61997, 73787].
DR   EMBL; AL929587.5; [-23391, 37967].
DR   EMBL; AY066019.1; [-588, 4242].
DR   EMBL; AY214167.1; [-1737, 5503].
DR   EMBL; BX248519.7; [-7954, 32206].
DR   SWISS-PROT; P01375; TNFA_HUMAN.
DR   TRANSFAC; R03186; HS$TNFA_01; [-125, -81]; by position.
DR   TRANSFAC; R08185; HS$TNFA_02; [-160, -142]; by position.
DR   TRANSFAC; R08186; HS$TNFA_03; [-121, -106]; by position.
DR   TRANSFAC; R08187; HS$TNFA_04; [-104, -86]; by position.
DR   TRANSFAC; R08188; HS$TNFA_05; [-84, -66]; by position.
DR   TRANSFAC; R14422; HS$TNFA_06; [-186, -173]; by position.
DR   TRANSFAC; R14423; HS$TNFA_08; [-174, -159]; by position.
DR   TRANSFAC; R14470; HS$TNFA_10; [-112, -91]; by position.
DR   TRANSFAC; R14565; HS$TNFA_11; [-103, -83]; by position.
DR   TRANSFAC; R14622; HS$TNFA_12; [-60, -25]; by position.
DR   TRANSFAC; R14623; HS$TNFA_13; [-78, -68]; by position.
DR   TRANSFAC; R14625; HS$TNFA_15; [-120, -107]; by position.
DR   TRANSFAC; R14632; HS$TNFA_16; [-172, -149]; by position.
DR   TRANSFAC; R14707; HS$TNFA_18; [-186, -173]; by position.
DR   TRANSFAC; R14708; HS$TNFA_17; [-60, -43]; by position.
DR   TRANSFAC; R21079; HS$TNFA_21; [-117, -81]; by position.
DR   TRANSFAC; R21082; HS$TNFA_22; [-117, -63]; by position.
DR   TRANSFAC; R24498; HS$TNFA_24; [-217, -199]; by position.
DR   TRANSFAC; R24499; HS$TNFA_25; [-112, -92]; by position.
DR   TRANSFAC; R24500; HS$TNFA_26; [-112, -92]; by position.
DR   RefSeq; NM_000594.
DR   MIM; 191160.
XX
RN   [1]
RX   MEDLINE; 2995927.
RA   Nedwin G.E., Naylor S.L., Sakaguchi A.Y., Smith D.,
RA   Jarrett-Nedwin J., Pennica D., Goeddel D.V., Gray P.W.;
RT   "Human lymphotoxin and tumor necrosis factor genes: structure,
RT   homology and chromosomal localization";
RL   Nucleic Acids Res. 13:6361-6373(1985).
XX
ME   Nuclease protection with homologous sequence ladder [1].
XX
SE   cgccctcctctcgccccagggacatataaaggcagttgttggcacacccAGCCAGCAGAC
XX
TX   6. Vertebrate promoters
TX   6.1. Chromosomal genes
TX   6.1.5. Hormones, growth factors, regulatory proteins
TX   6.1.5.11. Tumor necrosis factors
XX
KW   Cytokine, Cytotoxin, Transmembrane, Glycoprotein.
XX
FP   Hs TNF-a'           :+S  EU:NC_000006.10      1+  31651317; 11158.211
XX
DO        Experimental evidence: 3h
DO        Expression/Regulation: monocytes, macrophages;+LPS
RF        NAR13:6361
//