13-04-2016 -- Release of EPD version 127

This resource allows the access to several databases of experimentally validated promoters: EPD and EPDnew databases. They differ by the validation technique used and the coverage. EPD is a collection of eukaryotic promoters derived from published articles. Instead, the EPDnew databases (HT-EPD) are the result of merging EPD promoters whith in-house analysis of promoter-specific high-throughput data for selected organisms only. This process gives EPDnew high precision and high coverage.

EPDnew is a collection of databases of experimentally validated promoters for selected model organisms. Evidence comes from TSS-mapping from high-throughput expreriments such as CAGE and Oligocapping. The resulting databases are the following:
  • Animals:
    • H. sapiens: 23360 promoters,
    • M. musculus: 21239 promoters,
    • D. melanogaster: 15073 promoters,
    • D. rerio: 10728 promoters,
    • C. elegans: 7120 promoters;
  • Plants:
    • A. thaliana: 10229 promoters;
  • Fungi:
    • S. cerevisiae: 4324 promoters,
    • S. pombe: 3440 promoters.
The Eukaryotic Promoter Database is an annotated non-redundant collection of eukaryotic POL II promoters, for which the transcription start site has been determined experimentally. Access to promoter sequences is provided by pointers to positions in nucleotide sequence entries. The annotation part of an entry includes description of the initiation site mapping data, cross-references to other databases, and bibliographic references. EPD is structured in a way that facilitates dynamic extraction of biologically meaningful promoter subsets for comparative sequence analysis. This database contains 4806 promoters from several species.

Please cite us using the following references:

Promoters analysis tools:
The Eukaryotic Promoter Database: expansion of EPDnew and new promoter analysis tools. Dreos, R., Ambrosini, G., Périer, R., Bucher, P. Nucleic Acids Res. (2014) doi: 10.1093/nar/gku1111; PMID: 25378343

EPDnew methods description:
EPD and EPDnew, high-quality promoter resources in the next-generation sequencing era. Dreos, R., Ambrosini, G., Périer, R., Bucher, P. Nucleic Acids Res. (2013) 41(Database issue):D157-64; PMID: 23193273

Last update Aug. 2015